Katsuro Tachibana
Department of Anatomy, Fukuoka University School of Medicine, 7-45-1, Nanakuma, Jonan, 814-0180, Fukuoka, Japan
Available online 8 October 2004.
Abstract
Ultrasound has been in use in medicine for half a century as a modality
for diagnostic imaging and therapy. Recently, there have been numerous
reports on the application of thermal and nonthermal ultrasound energy
for treating various diseases in the brain. In addition to thermal
ablation of brain tumors, nonthermal ultrasound combined with drugs has
led to much excitement especially for vascular diseases in the brain and
regenerative medicine. Ultrasound energy can enhance the effects of
thrombolytic agents such as urokinase for treatment of stroke.
Therapeutic ultrasound catheters are currently being developed.
Noninvasive methods such as high-intensity focused ultrasound (HIFU) in
conjunction with magnetic resonance image (MRI) and CT are already being
applied in the clinical field. Chemical activation of drugs by
ultrasound energy for treatment of tumors is another new field recently
termed “Sonodynamic Therapy”. Combination of genes and microbubble has
induced great hopes for application of gene therapy to the brain.
Various examples of ultrasound combined modalities are under
investigation which could lead to revolutionary brain therapy.
Keywords: Drug delivery; Brain; Stroke; Gene therapy
Sumber: http://physioture.blogspot.com/2008/11/ultrasound-therapy-for-stroke-and.html
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